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25th Meeting of the European Red Cell Society

From April 19-23, 2024 we are organizing the 25th meeting of the European Red Cell Society. The meeting will be held at Westcord Hotel Noordsee, Ameland, the Netherlands.

This biannual International meeting attracts leading experts in the fields of erythropoiesis, red blood cell physiology and function, and red blood cell related disorders. It is an event that brings together 100+ people from Europe and beyond, and connects the fields of research, diagnostics and clinical implications. The target audience are researchers (basic and translational), laboratory specialists, hematologists, and PhD students.

The content of this 4 day course is the responsibility of the program committee, consisting of:
Dr. Emile van den Akker, dr. Robin van Bruggen, and dr. Marieke von Lindern (Sanquin, Amsterdam, The Netherlands)
Dr. Cees Harteveld (Leiden University Medical Center, Leiden, The Netherlands)
Dr. Marije Bartels, dr. Minke Rab, dr. Richard van Wijk (University Medical Center Utrecht, Utrecht, The Netherlands)

Friday, April 19
  • 15:00 – 16:00

    Outward journey Holwerd-Nes

  • 16:45 – 17:30
    • Check-in hotel

  • 18:30 – 19:30

    Keynote lecture – Merav Socolovsky

  • 19:30 – 21:30

    Buffet dinner

Saturday, April 20
  • 8:00 – 09:00

    Breakfast

Scientific session 1 – Erythropoiesisstyle

  • 9:00 – 09:30

    Lionel Blanc

  • 9:30 – 09:45

    Anemia links β-catenin with FOXO3 signaling during erythroid terminal differentiation
    Santhe van der Meulen, Sanquin
     

  • 9:45 – 10:00

    In vitro culture of erythroblasts (EBL) and production of mature erythrocytes for transfusions requires upscaling in fluidic-turbulent
    Giuliana Iacono, Sanquin 

  • 10:00 – 10:15

    The Role of the Zcchc6/Dis3L2 RNA Editor-Exonuclease Axis in Terminal Erythroid Differentiation
    Areum Han, Harvard Medical school / Boston’s Children Hospital
     

  • 10:15 – 10:30

    Transfusion-ready red blood cell generation from induced pluripoten stem cells (iPSCs)
    Emile van den Akker
    , Sanquin

  • 10:30 – 10:45

    Detailed characterization of iPSC-derived hematopoiesis and erythropoiesis en self-organized cellular complexes (hemanoids)
    Isabel Dorn, Medical University Graz, Austria


  • 10:45 – 11:15

    Coffee break

Scientific session 2 – Disorders of Erythropoiesisstyl

  • 11:45 – 12:15

    Sjaak Philipsen

  • 11:45 – 12:00

    Ineffective erythropoiesis negatively impacts the erythroblastic island in sickle cell disease
    Wassim El Nemer, EFS Sante, France

  • 12:00 – 12:15

    Anemia in aged mice is accompanied by reduced erythroid lineage cell production and increased red blood cell life span
    Carsten Alt, Pfizer

  • 12:15 – 12:30

    Development of a beta-thalassemia rat model for bone marrow characterization after stem cell transplantation
    K. Roemhild, Sanquin

  • 12:30 – 12:45

    Elucidating glucocorticoid-responsiveness in Diamond-Blackfan anemia syndrome using iPSC-derived erythroblasts
    Teun Slijkerman, Sanquin


  • 12:45 – 13:45

    Lunch

  • 13:45 – 16:00

    Networksession
    ‘Meet the expert’ session with Ingolf Benhardt
    Unsolved problems in red cell research
    Ingolf Benhardt University Saarland, Germany

Scientific session 3 – Red blood cell membrane and associated disorders

  • 16:15 – 16:45

    Lydie da Costa

  • 16:45 – 17:00

    Developmental changes in membrane lipid composition during terminal maturation of circulating human reticulocytes and ageing of red cells
    Minetti, Unive….

  • 17:00 – 17:00

    Modulation of terminal erythropoiesis by a TSPO ligand
    Sophie Lefèvre,
           ……

  • 17:15 – 17:30

    Complete absence of GLUT1 does not impair human terminal erythroid differentiation
    Catarina Freire, Bristol

  • 17:30 – 17:45

    Red Blood Cell Protein contribution to Malaria Parasite Invasion. Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter
    Timothy Satchwell, University Bristol, UK


  • 19:00 – 21:30

    Buffet Dinner

Sunday, April 21
  • 8:00 – 09:00
    • Breakfast

Scientific session 4 – Ion channels of the red blood cell – function and disorders

  • 9:00 – 09:30

    Paola Bianchi

  • 9:30 – 09:45

    Electrophysiological characterization of red blood cells using the automated patch clamp
    Nicoletta Muarciano, Nanion

  • 9:45 – 10:00

    Role of Piezo 1 in terminal density reversal of healthy red blood cells
    Kuntal Dey,

  • 10:00 – 10:15

    Dual action of Dooku1 on PIEZO1 channel in human red blood cells
    Guillaume Bouyer, France


  • 10:15 – 10:45

    Coffee break

Scientific session 5 – Clinical hematology – new treatments in sickle cell disease and other hereditary red blood cell disorders

  • 10:45 – 11:15

    Erfan Nur

  • 11:15 – 11:30

    Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling
    Nicolas Hebert, Etablissement Francais Du Sand, France

  • 11:30 – 11:45

    Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease
    M. van Dijk,
    UMC Utrecht, the Netherlands

  • 11:45 – 12:00

    Plasma Proteome Profiling of Sickle Cell Patients Reveals Activation of Inflammatory Pathways During Steady State and Vaso-occlusive Crisis
    Lydian de Ligt, Amsterdam UMC, the Netherlands

  • 12:00 – 12:15

    Red cell rheology and blood viscosity in individuals with sickle cell disease following allogenic bone marrow transplantation or autologous gene addition therapy
    Vivien Sheehan, Emory University of medicine, United States

  • 12:15 – 12:30

    A novel allosteric activator of pyruvate kinase enhances human and mouse enzymatic activity and leads to ematological improvements in sickle cell disease mouse models
    Carsten Alt, Pfizer


  • 12:45 – 13:45

    Lunch

  • 13:45 – 14:15

    Sponsored session
    Presentation by RR Mechatronics

  • 14:15 – 18:00

    Network session

  • 19:00 – 21:30

    Buffet Dinner

Monday, April 22
  • 8:00 – 09:00
    • Breakfast

Scientific session 6 – New developments for red cell research  and diagnostics

  • 9:00 – 09:30

    Lars Kaestner

  • 9:30 – 09:45

    An Efficient and Specific Reporter System Suitable for High-Throughput Screening of Novel Fetal Hemoglobin Inducers
    Tingyue Li, ErasmusMC,
     Rotterdam, the Netherlands

  • 9:45 – 10:00

    Pyruvate Kinase Thermostability Is Associated with Red Blood Cell Adhesion, Deformability and Oxygen Affinity in Patients with Sickle Cell Disease
    M. Traets, UMC Utrecht, the Netherlands

  • 10:00 – 10:15

    Towards quantification of intracellular free calcium in individual red blood cells by fluorescence lifetime imaging microscopy
    Min Qiao

  • 10:15 – 10:30

    Ex vivo glycolytic flux measurements in red blood cells
    Titine de Ruiter, UMC Utrecht, the Netherlands

  • 10:30 – 10:45

    Hepatic Leukemia Factor as a marker for iPSC – derived Hematopoietic Stem Cells
    M. Simanovich, Erasmusmc Rotterdam, the Netherlands


  • 10:45 – 11:15

    Coffee break

Scientific session 7 – New developments for red cell research and diagnostics

 – Clinial cases

  • 11:15 – 11:45

    SUPT5H nonsense variants as modifying factor in beta-thalassemia trait
    Kees Harteveld, Leiden University MC, The Netherlands

– New developments for red cell research and diagnostics

  • 11:45 – 12:00

    An AI-based imaging flow cytometry approach to study erythrophagocytosis
    S. Neri, Sanquin

  • 12:00 – 12:15

    Endothelialized 3D perfusion model to study ex vivo reticulocyte-to-erythrocyte transition
    Claudia Maria Bernecker

  • 12:15 – 12:30

    Actomyosin-driven expulsion of hemoglobin during hemolysis,
    Tessa Korsa

  • 12:30 – 12:45

    Red cell function devices under development for use in sickle cell disease
    Vivien Sheehan


  • 12:45 – 13:45

    Lunch

Scientific session 8 – Clinical hematology – new diagnostic approaches & Ion Channels

  • 13:45 – 14:15

    Minke Rab

  • 14:15 – 14:30

    Novel direct plasma heme-related assay decyphers hemolytic anemia and ineffective erythropoiesis Nicolas Hebert

  • 14:30 – 14:45

    Impact of Sickle Cell Disease Patients-Derived Red Blood Cells on Clot Dynamics and Fibrin Structure
    N. Ouazzanichahdi, Sanquin

  • 14:45 – 15:00

    Low Voxelotor Concentrations Exacerbate Sickle Cell Formation At Low Oxygen Pressure
    Emile van den Akker, Sanquin

  • 15:00 – 15:15

    Soluble Transferrin Receptor as a Marker for Assessing Disease Severity in  Hereditary Hemolytic Anemias Marije Bartels, UMC Utrecht

  • 15:15 – 15:30

    Autoimmune hemolytic anemia anti-RBC IgM, but not IgG, drive in vitro complement activation
    Femke Mulder, Sanquin

  • 15:30 – 15:45

    Ion channels of the red blood cell:
    Effects of Pyruvate Kinase Activation in Hereditary Hemolytic Anemia
    Jonathan de Wilde, UMC Utrecht, the Netherlands


  • 16:00 – 16:30

    Coffee break

  • 16:30 – 17:30

    ERCS General Assembly meeting 

  • 17:30 – 21:30

    Poster session and dinner

Tuesday, April 23
  • 07:45 – 08:45

    Breakfast and checkout

  • 08:45

    Departure from hotel by bus

  • 09:00

    Departure to mainland

This conference is made possible by